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dextran sulfate sodium dss induced colitis model  (Valiant Co Ltd)

 
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    Structured Review

    Valiant Co Ltd dextran sulfate sodium dss induced colitis model
    Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
    Dextran Sulfate Sodium Dss Induced Colitis Model, supplied by Valiant Co Ltd, used in various techniques. Bioz Stars score: 98/100, based on 2082 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/dextran+sulfate+sodium+dss+induced+colitis+model/Dextran/pmc13023902-129-1-12
    Average 98 stars, based on 2082 article reviews
    dextran sulfate sodium dss induced colitis model - by Bioz Stars, 2026-09
    98/100 stars

    Images

    1) Product Images from "Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator"

    Article Title: Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator

    Journal: Biomedicines

    doi: 10.3390/biomedicines14030687

    Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
    Figure Legend Snippet: Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.

    Techniques Used: Western Blot, Expressing, Knockdown, Activity Assay, Staining

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    Molecular Weight:

    Article Title: Novel Potassium-Competitive Acid Blocker, Tegoprazan, Protects Against Colitis by Improving Gut Barrier Function
    Article Snippet: .. Dextran sulfate sodium (DSS)-induced colitis model In experiment using filgotinib, experimental ulcerative colitis was induced by administering 2.5% (w/v) DSS (molecular weight: 36–50 kDa, 160110, MP Biomedicals, Santa Ana, CA, USA) in distilled drinking water for 5 days, followed by normal drinking water for 4 days. ..

    Article Title: Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator
    Article Snippet: .. A dextran sulfate sodium (DSS)-induced colitis model was generated with 2.5% DSS (MP Biomedicals, molecular weight 35,000–50,000 Da). .. To explore the role of CBX4 in colitis pathogenesis, C57BL/6 mice (GemPharmatech, Nanjing, China) were randomly divided into four experimental groups: scramble-NC, sh-CBX4-NC, scramble-DSS, and sh-CBX4-DSS (Hanbio Biotechnology, Shanghai, China).

    Generated:

    Article Title: Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator
    Article Snippet: .. A dextran sulfate sodium (DSS)-induced colitis model was generated with 2.5% DSS (MP Biomedicals, molecular weight 35,000–50,000 Da). .. To explore the role of CBX4 in colitis pathogenesis, C57BL/6 mice (GemPharmatech, Nanjing, China) were randomly divided into four experimental groups: scramble-NC, sh-CBX4-NC, scramble-DSS, and sh-CBX4-DSS (Hanbio Biotechnology, Shanghai, China).

    other:

    Article Title: Angelicin: A promising tricyclic aromatic agent for ulcerative colitis through cysteine-mediated proliferation of intestinal epithelial cells
    Article Snippet: 87 In the dextran sulfate sodium (DSS)-induced colitis model, mice (C57BL/6 strain) were 88 given 3% DSS (MP Biomedicals, Santa Ana, CA, USA) dissolved in drinking water over a 89 7-day period.

    Concentration Assay:

    Article Title: Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity.
    Article Snippet: The signals were captured on X-ray film (Tanon) for visualization. .. Dextran Sulfate Sodium (DSS) Induced Colitis Model: DSS (MP Biomedicals, Cat#0216011090) was dissolved in drinking water to the concentration of 2%. ..

    Knock-Out:

    Article Title: TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis.
    Article Snippet: Triggering receptor expressed on myeloid cells 2 (TREM2) has been implicated in the pathogenesis of inflammatory bowel disease (IBD), yet its role in microbiota-mediated intestinal immune homeostasis remains incompletely defined.. Here, we demonstrate that TREM2 expression is associated with exacerbated colonic inflammation in a murine model of DSS-induced colitis, disrupting epithelial integrity and microbial homeostasis.. TREM2 transgenic (TG) mice developed more severe disease and mucosal injury, accompanied by marked dysbiosis characterized by the expansion of pro-inflammatory taxa (Firmicutes, Actinobacteria, Prevotella) and depletion of beneficial commensals (Lactobacillus, Bifidobacterium).

    Transgenic Assay:

    Article Title: TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis.
    Article Snippet: Triggering receptor expressed on myeloid cells 2 (TREM2) has been implicated in the pathogenesis of inflammatory bowel disease (IBD), yet its role in microbiota-mediated intestinal immune homeostasis remains incompletely defined.. Here, we demonstrate that TREM2 expression is associated with exacerbated colonic inflammation in a murine model of DSS-induced colitis, disrupting epithelial integrity and microbial homeostasis.. TREM2 transgenic (TG) mice developed more severe disease and mucosal injury, accompanied by marked dysbiosis characterized by the expansion of pro-inflammatory taxa (Firmicutes, Actinobacteria, Prevotella) and depletion of beneficial commensals (Lactobacillus, Bifidobacterium).

    Sterility:

    Article Title: TREM2 promotes susceptibility to colitis through the induction of gut microbiota dysbiosis.
    Article Snippet: Triggering receptor expressed on myeloid cells 2 (TREM2) has been implicated in the pathogenesis of inflammatory bowel disease (IBD), yet its role in microbiota-mediated intestinal immune homeostasis remains incompletely defined.. Here, we demonstrate that TREM2 expression is associated with exacerbated colonic inflammation in a murine model of DSS-induced colitis, disrupting epithelial integrity and microbial homeostasis.. TREM2 transgenic (TG) mice developed more severe disease and mucosal injury, accompanied by marked dysbiosis characterized by the expansion of pro-inflammatory taxa (Firmicutes, Actinobacteria, Prevotella) and depletion of beneficial commensals (Lactobacillus, Bifidobacterium).



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    Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
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    Silencing CBX4 alleviates <t>DSS-Induced</t> UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.
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    Image Search Results


    Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.

    Journal: Biomedicines

    Article Title: Integrative Transcriptomics and Machine Learning Reveal the Association of CBX4 with Inflammation in Ulcerative Colitis as a Potential Epigenetic Regulator

    doi: 10.3390/biomedicines14030687

    Figure Lengend Snippet: Silencing CBX4 alleviates DSS-Induced UC in Mice. ( A ) Western blot analyses showing CBX4 expression in the colons of mice following knockdown. ( B ) Body weight change in different groups. ( C ) The Disease Activity Index (DAI) in different groups. ( D , E ) Statistical analysis of colon length. ( F ) H&E staining. Scale bar = 100 μm. Data were presented as mean ± SD, n = 6. *** p < 0.001. ### p < 0.001 vs. EV-DSS group.

    Article Snippet: A dextran sulfate sodium (DSS)-induced colitis model was generated with 2.5% DSS (MP Biomedicals, molecular weight 35,000–50,000 Da).

    Techniques: Western Blot, Expressing, Knockdown, Activity Assay, Staining